TETRA Tissue-to-Metamaterial Builder v8.0

TETRA Tissue-to-Metamaterial Builder v8.0 provides an integrated research environment for converting microscopy images into metamaterial-based representations of biological tissues. It combines tissue morphology, simulated cell mechanics, electromagnetic modelling, optical propagation, and exploratory cancer-region analysis.

Main functionalities

  • Uploading and segmenting microscopy images
  • Generating spatial dielectric permittivity and anisotropy maps
  • Modelling tissue mechanical and electromagnetic properties
  • Interactive 3D tissue visualization
  • Highlighting regions with potentially cancer-associated morphological and physical characteristics
  • Comparing research predictions with pathology annotations
  • Performing multicentre validation and uncertainty analysis
  • Generating scientific figures and research reports

User Guide

  1. Upload a microscopy image
    • Open the application and navigate to Section 1 — Tissue morphology.
    • Under Input mode, select Upload tissue micrograph.
    • Click Choose File and upload a microscopy image in PNG or JPEG format.
    • Adjust the Dark-region segmentation threshold and Minimum structure area parameters to obtain an appropriate tissue segmentation.
  2. Generate a metamaterial representation
    • After uploading and segmenting the image, examine the Spatial model panel.
    • The application displays the segmented tissue morphology and a corresponding modelled relative permittivity map.
    • Click Export dielectric PNG to save the generated metamaterial representation.
  3. Perform advanced electromagnetic modelling
    • Use the tensor-field estimation tools to explore spatial dielectric anisotropy.
    • Run optical polarization simulations to investigate modelled electromagnetic responses.
    • Open Spatial Scientific Visualization (Section 63) to visualize dielectric tensor components and polarization-response maps when the required numerical data are available.
  4. Explore tissue regions in three dimensions
    • Use Interactive 3D Tissue & Tensor Explorer (Section 64) to examine reconstructed tissue morphology and spatial dielectric properties.
    • Use Exploratory 3D Region Prioritization (Section 65) to investigate combinations of morphology, simulated mechanics, and electromagnetic anisotropy.
  5. Evaluate and document research results
    • Use the pathology benchmarking and multicentre validation modules to compare model outputs with independently supplied experimental data.
    • Open Integrated Cancer-Recognition Research Dashboard (Section 71) to review available research evidence.
    • Use Scientific Publication Package Builder (Section 72) to generate scientific report drafts.
  6. Export results
    • Depending on the selected module, users can export PNG visualizations, numerical CSV/JSON files, and scientific reports.

The application also contains synthetic demonstration datasets that allow users to explore its functionalities without uploading experimental images.

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